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Nevertheless, since GSH cannot be administered directly—because of its insufficient absorption, stability and solubility—analogues have been obtained, through modifications at the γ-glutamyl, cysteine and glycine moieties, and/or the functionalisation of the central cysteine, that are able to inhibit the activity of GSTs 69,87,105
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Here’s what research and expert opinions reveal: Melanin Reduction Effect: Glutathione’s primary role in skin lightening involves inhibiting tyrosinase, an enzyme responsible for melanin production in the skin
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