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for example, TNF-α promotes lipolysis through MEK–ERK activation and increased cAMP signaling (Zhang et al., 2002), and TNF-β has emerged as a potential biomarker linking inflammation to metabolic dysregulation in MetS ( Under physiological conditions, adipose-derived mesenchymal stromalcells (ADMSCs) play a pivotal role in maintaining inflammatory homeostasis through tightly regulated interactions with immune cells and metabolic signaling pathways