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Such behavioral deficits in A53T mice were accompanied by the presence of elevated α-synuclein monomers and aggregates (Supplemental Figure 1J) and a remarkable loss of dopaminergic neurons in the substantia nigra, as indicated by tyrosine hydroxylase (TH) staining (Figure 1C)

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Co-culture of epithelial progenitor cells isolated from aged mice with MSCs or with membrane vesicles isolated from the MSCs of young mice resulted in the rejuvenation of “old” epithelial progenitor cells [87]