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Oestrogens produced by astrocytes may play a role in controlling glutamate metabolism in the brain through their efficient interaction with human GDH2 ( Finally, research has shown that an uncommon GLUD2 gene variant, T1492G, which causes a gain-of-function Ser445Ala substitution in hGDH2, is linked to the onset of early-onset Parkinson’s disease in some populations ( Conclusion GDH is an essential metabolic enzyme that links glutamate to numerous other metabolic pathways

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& Roizman, B