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Under normal condition, there is a balance between the systemic ROS production and biological antioxidants' capacity to remove the oxidants or to repair the oxidative stress induced damages

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2) based on urate absorption, some of the variants truncate a protein that may have a termination codon that leads to the loss of URAT1 function ( ABCG2 The ATP binding cassette subfamily member 2 (ABCG2), a multi-specific transporter, is located on the apical membrane in tissues including kidney and intestine