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Upon stimulation, inositol 1,4,5-trisphosphate receptors on the ER release stored Ca2+ near the mitochondrial outer membrane, where it is taken up via the voltage-dependent anion channel-MCU pathway
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in the Journal of Clinical Endocrinology and Metabolism (2006) demonstrated that combined GHRH and GHS administration produces GH release that exceeds the sum of either agent alone โ a true synergistic effect