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Quick Take (TLDR) Mostly animal and in vitro data plus multiple very small uncontrolled human reports (knee pain case series n=16, interstitial cystitis pilot n=12, 2‑subject IV infusion) and no randomized controlled trials or published human pharmacokinetic profiles

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The benefits of triple agonism extended also to MASLD – in a subgroup of 98 people, fat content normalised in approximately 90% of people receiving the highest retatrutide doses [82]