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The crude extract fraction and all pure compounds: Harmine, harmaline, tetrahydroharmine, harmol, and harmaloi from Harmal produced antihypertensive effects in anesthetized rats in a dose-dependent manner.[86,87] Punica granatum or Pomegranate Pomegranate is from Lythraceae family

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Clinical data across hundreds of participants shows serious adverse events are essentially nonexistent with topical use