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In ME/CFS, an increased prevalence of the class II major histocompatibility complex HLA-DQB*01 allele (88), along with two other variants of HLA-DQB1 in combination with two RAGE-374A variants (489) was found

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They were subsequently used as a vaccination to activate immunological responses in Tg mice, which produce the 140-amino-acid full-length protein α-synuclein (B6