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Inactivating this pathway, whether spontaneously or through intervention, triggers factors that induce ferroptosis, underscoring the importance of regulating ferroptosis in cancer treatment (124)

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For example, dasatinib and quercetin reduce SASP cytokines by promoting apoptosis of ROS-rich senescent cells, while fisetin decreases oxidative stress burden and downregulates NF-κB signaling, thereby dampening SASP output