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146 Sapidolide A, extracted from a folk medicine used in China to treat inflammatory diseases, inhibits expression and activation of the NLRP3 inflammasome when used as a pretreatment in a mouse model of APAP-induced liver injury

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Functional studies in primary dermal fibroblasts derived from the patient and family members indicated that IGF1R mRNA expressed from the mutant allele was degraded through the nonsense-mediated mRNA decay pathway resulting in reduced amount of wild-type IGF1R protein and, subsequently, diminished activation of the IGF1R pathway