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The mechanism in which Bcl-2 prevents GSH export is not yet understood, although a recent paper suggests that there is an interaction between the BH3 domain of Bcl-2 and GSH (Zimmermann et al., 2007)

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As a permanently charged quaternary cation it is water-soluble and does not require organic cosolvent for aqueous work, though DMSO stocks are common in cell-based screens