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TB-500 is a considerably larger, highly charged polypeptide dominated by lysine, glutamate and aspartate residues, with an N-terminal acetyl cap and a single methionine that is often monitored as an oxidation-prone site during stability and forced-degradation studies

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In some instances, due to conditions such as pernicious anaemia, the body may struggle to absorb enough B12 from diet alone, necessitating supplementation