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As discussed earlier, many of the compounds are capable of scavenging a number of different ROS and many may also decrease ROS by inhibiting endogenous ROS production [19]

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Abbreviations BSO L-buthionine sulfoximine γ-GCL γ-glutamylcysteine ligase GSH glutathione MRP multi-drug resistant protein ELF epithelial lining fluid BALF bronchoalveolar lavage fluid SOD superoxide dismutase IPF idiopathic pulmonary fibrosis ARDS acute respiratory distress syndrome CF cystic fibrosis COPD chronic obstructive pulmonary disease GCL γ-glutamylcysteine ligase GGT γ-glutamyl transpeptidase ABC ATP binding cassette proteins MRP multidrug resistance protein CFTR cystic fibrosis transmembrane conductance regulator ENaC Epithelial sodium channel PA Pseudomonas aeruginosa BCRP breast cancer related protein GSSG glutathione disulfide NAC N-acetylcysteine ARE antioxidant response element Footnotes Publisher's Disclaimer: This is a PDF file of an unedited manuscript that has been accepted for publication