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Mice with a deficiency of key components in the NF-κB pathway die as a result of massive hepatocyte apoptosis induced by TNFα 37,38 , supporting the critical role of maintenance of hepatocyte NF-κB pathway in protecting against TNFα cytotoxicity

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Furthermore, energy metabolism impairments, particularly in the tricarboxylic acid (TCA) cycle, were also implicated in AD (Sun C

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