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3.5 Subgroup analysis To address the considerable heterogeneity observed across studies, we performed subgroup analyses focusing on three confounding factors (animal species, treatment agents, model drugs and dosages), to identify the sources of heterogeneity for the five primary outcomes (AST, ALT, SOD, MDA, GSH)

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Moreover, overexpression of PPARα markedly upregulated GPX4 expression and downregulated ACSL4 expression in HMCs [274]