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The review documented that GSH and GSH-dependent enzymes including GST regulate the cellular survival of multiple cancer types including prostate, lung, breast, and colon cancer

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Our results suggest that CBS of the TSS pathway plays an important role in maintaining cysteine levels under restricted cystine availability or excess hemin exposure, and CBS upregulation by DMF increases the cellular glutathione levels to protect against ROS and ferroptosis stress in SCD