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Necroptosis can also be materialized as a result of activation of the signaling pathways, due to DNA damage, which leads to the release of apoptosis-related factors from the mitochondrial intermembrane space, followed by the activation of the DNA damage–related enzyme poly(ADP-ribose) polymerase (PARP) [213]
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The management of patients include patient-reported outcomes for long-term follow-up care and for early detection of possible adverse events and the use of digital technologies, such as telemedicine - videoconferences for patients’ follow-up and reinfection risk elimination, digital therapeutics approach, especially for non-pharmaceutical interventions (e.g., breathing exercises), electronic control of body parameters such as temperature, oxygen saturation, blood pressure, that can be measured with wearable devices and the data can be analyzed with artificial intelligence (256, 257)
