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The headache phase follows the prodromal or aura stages of a migraine, marked by the activation and sensitization of the trigeminovascular system (TVS) and brainstem, leading to disrupted sensory processing and various neurological symptoms indicative of altered brain excitability (29)

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196,197,198 The phosphorylation of Akt is necessary for its full activation, allowing it to regulate a variety of downstream effector proteins involved in cell survival, proliferation, metabolism, and glucose transport