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PE-22-28 Safety Considerations# PE-22-28's safety profile is less burdened by mechanism-specific concerns: TREK-1 channels are expressed throughout the body (brain, heart, vasculature, gastrointestinal tract), so systemic TREK-1 blockade could theoretically affect cardiovascular function, pain sensation, and gastrointestinal motility

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Both studies administered B12 i.m., one used methyl-B12 at a dose of 500 µg three times per week for 2 weeks, 63 the other used cyano-B12, 1000 µg daily for 2 weeks

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