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More recently, it has been demonstrated that ROS are also involved in activation and regulation of a wider range of processes in the innate immune system, including autophagy, signal transduction, gene expression, activation of the inflammasome, and programmed necrosis [15], [16], [24]–[28]

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Another point of view is that necroptosis and ferroptosis function independently in many pathologies that involve cell death, but that they are alternative pathways in murine renal IRI

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