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[4] BPC-157 also interacts with the dopaminergic and serotonergic systems in the central nervous system, modulates the hypothalamic-pituitary-adrenal axis, and has documented effects on growth hormone receptor expression

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Directly targeting mitochondria with gamitrinib, a small-molecule HSP90 inhibitor, or Phenformin, an inhibitor targeting mitochondrial respiratory complex I, increased apoptosis and cell death in melanoma cells treated with MAPKi [54]