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For instance, despite the aforementioned association between IGFBP-5 and metastasis, forced-overexpression of IGFBP-5 in breast cancer cell lines actually inhibits cell growth [71]

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A major enzyme of steroid hormone metabolism that utilizes NADPH is the ER-localized 11β-hydroxysteroid dehydrogenase 1 (11β-HSD1) which is encoded by the HSD11B1 gene