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The trial proceeded without reported toxicity, and no lethal dose threshold (LD1) was ever established in subsequent safety testing — meaning researchers administering the compound could not find a dose that caused death in even 1% of test subjects across the animal model safety work that preceded and followed the human study

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Drought and heat can also hinder a plant’s capacity to synthesize secondary compounds, essential for protection against insect pests (Shafi et al., 2024)