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Overall, botulinum neurotoxin A injection, intravesical sodium hyaluronate instillation and DMSO instillation seem to be the best-performing treatments, with response rates of 79%, 76% and 75%, respectively, and can be used effectively as second-line or third-line therapies for BPS/IC

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Consequently, considering the application and efficacy of standard agents, a considerable gap remains between the theoretical potential and practical realization[1,7]