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SAM is the universal methyl donor for: DNA methylation (DNMT enzymes), which regulates gene expression and genomic stability Histone methylation, which alters chromatin architecture and gene accessibility Catecholamine inactivation via COMT (catechol-O-methyltransferase), relevant to dopamine and norepinephrine metabolism Phosphatidylcholine synthesis via PEMT, relevant to liver health Shifting SAM availability upward sounds beneficial, but the one-carbon cycle is a buffered system